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KMID : 0378019900330010069
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New Medical Journal
1990 Volume.33 No. 1 p.69 ~ p.74
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The Effect of Phenobarbital on Neonatal Hyperbilirubinemia
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이철호/Lee, Chul Ho
이의재/조보경/전정식/조성훈/Yi, Eui Jae/Cho, Bo Kyung/Chun, Chung Sik/Cho, Sung Hoon
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Abstract
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Neonatal hyperbilirubinemia is one of the common problems in the newborn period. Phenobarbital is the most investigated agent which diminish the serum bilirubin level when administered early in neonatal life. Authors compared the levels of 3rd, 7th day bilirubin be ween phenobarbital treated group (32 neonates) and untreated control group (20 neonates). We also analyzed the effect of phenobarbital between 3 days oral treated group and one time IM treated group.
The results are as follows:
1. On 3rd day, the mean serum bilirubin level of IM group was lower than that of control group but that of PO group was lower than that of control group on 7th day (p<0.01, p<0. 01 respectively).
2. In full term neonates, the mean serum bilirubin level of both PO, IM group was lower than that of control group on 7th day (p<0.05, p<0.05 respectively).
3. In premature neonates, there was no significant difference between the mean ?rum bilirubin levels of both PO, IM group and control group.
4. In full term neonates, the mean of phenobarbital blood concentration of PO group was higher than that of IM group on 7th day.
5. In premature neonates, the mean of phenobarbital blood concentration of -PO group was higher than that of IM group on 7th day.
These results suggested that the early administration of phenobarbital was effective in decreasing the serum bilirubin level in full term neonates, but less effective in premai res, and 3 day successive oral treated group showed more persistent effect than IM treated group.
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